FOXO4-D-Retro-Inverso (DRI) is a modified synthetic protein. The alteration extends the protein’s half-life and disrupts FOXO4’s function. FOXO4-DRI reduces FOXO4’s binding to p53, allowing the elimination of senescent cells, a younger “biological age” of tissue, and improved organ function. FOXO4-DRI affects insulin, cell cycle, and oxidative signalling. FOXO4-DRI reverses ageing in animals by triggering apoptosis in senescent cells.
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